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161 results

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Page 1
Correlation between 25-Hydroxyvitamin D, sFlt-1, PLGF, and Hypertension in Pregnancy.
Wang W, Du T, Jiang X. Wang W, et al. J Healthc Eng. 2021 Nov 1;2021:9371953. doi: 10.1155/2021/9371953. eCollection 2021. J Healthc Eng. 2021. PMID: 34760146 Free PMC article. Retracted.
The purpose of this study was to investigate the relationship between 25-hydroxyvitamin D, sFlt-1, and PLGF and hypertensive disorder complicating pregnancy. ...In the hypertensive pregnancy group, the level of 25-hydroxyvitamin D was 18.44 3.48 ng/ml, and the sF …
The purpose of this study was to investigate the relationship between 25-hydroxyvitamin D, sFlt-1, and PLGF and hypertensive d …
Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis.
Palmer KR, Tong S, Kaitu'u-Lino TJ. Palmer KR, et al. Mol Hum Reprod. 2017 Feb 10;23(2):69-78. doi: 10.1093/molehr/gaw077. Mol Hum Reprod. 2017. PMID: 27986932 Review.
This sFLT-1 variant is also the main sFLT-1 secreted from the placenta. ...Therefore, here we propose that sFLT-1 e15a may be the sFLT-1 variant primarily responsible for pre-eclampsia, a uniquely human disease. ...
This sFLT-1 variant is also the main sFLT-1 secreted from the placenta. ...Therefore, here we propose that sF …
Differential regulation of sFlt-1 splicing by U2AF65 and JMJD6 in placental-derived and endothelial cells.
Eddy AC, Chapman H, Brown DT, George EM. Eddy AC, et al. Biosci Rep. 2020 Feb 28;40(2):BSR20193252. doi: 10.1042/BSR20193252. Biosci Rep. 2020. PMID: 32039444 Free PMC article.
Our results showed that U2AF65 has little, if any, effect on sFlt-1 splicing, and JMJD6 may enhance sFlt-1 splicing, but is not necessary for splicing to occur. ...Additionally, we observed a potential role for U2AF65 and JMJD6 to regulate the extracel …
Our results showed that U2AF65 has little, if any, effect on sFlt-1 splicing, and JMJD6 may enhance sFlt-1 splic …
The correlation between serum levels and placental tissue expression of PLGF and sFLT-1 and the FIGO grading of the placenta accreta spectrum disorders.
Alessandrini L, Aryananda R, Ariani G, Agustina B, Akbar MIA, Dachlan EG, Dekker G, Ernawati E. Alessandrini L, et al. J Matern Fetal Neonatal Med. 2023 Dec;36(1):2183744. doi: 10.1080/14767058.2023.2183744. J Matern Fetal Neonatal Med. 2023. PMID: 36859823 Free article.
Soetomo Hospital (Academic Hospital of Universitas Airlangga, Surabaya, Indonesia) from May to September 2021. Venous blood samples for PLGF and sFlt-1 were drawn immediately prior to surgery. Placental tissue samples were taken during surgery. ...Serum PLGF …
Soetomo Hospital (Academic Hospital of Universitas Airlangga, Surabaya, Indonesia) from May to September 2021. Venous blood samples for PLGF …
Procyanidin B2 ameliorates endothelial dysfunction and impaired angiogenesis via the Nrf2/PPARgamma/sFlt-1 axis in preeclampsia.
Liu L, Wang R, Xu R, Chu Y, Gu W. Liu L, et al. Pharmacol Res. 2022 Mar;177:106127. doi: 10.1016/j.phrs.2022.106127. Epub 2022 Feb 10. Pharmacol Res. 2022. PMID: 35150862
A drug that is safe in pregnancy and inhibits placental sFlt-1 and soluble endoglin secretion would be an attractive treatment strategy for preeclampsia. ...Taken together, our results demonstrate that procyanidin B2 inhibits sFlt-1 secretion and ameli …
A drug that is safe in pregnancy and inhibits placental sFlt-1 and soluble endoglin secretion would be an attractive treatment …
Proteases and sFlt-1 release in the human placenta.
Zhao S, Gu Y, Fan R, Groome LJ, Cooper D, Wang Y. Zhao S, et al. Placenta. 2010 Jun;31(6):512-8. doi: 10.1016/j.placenta.2010.03.014. Placenta. 2010. PMID: 20434767 Free PMC article.
Although the reason for increased placental sFlt-1 release in PE is unknown, proteolytic effect has been proposed as one of the mechanisms that mediate sFlt-1 release in the placenta. ...Culture medium was collected and measured for sFlt-1 …
Although the reason for increased placental sFlt-1 release in PE is unknown, proteolytic effect has been proposed as one of th …
Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia.
Binder NK, Brownfoot FC, Beard S, Cannon P, Nguyen TV, Tong S, Kaitu'u-Lino TJ, Hannan NJ. Binder NK, et al. Pregnancy Hypertens. 2020 Oct;22:86-92. doi: 10.1016/j.preghy.2020.07.013. Epub 2020 Jul 28. Pregnancy Hypertens. 2020. PMID: 32758704
We assessed secretion of sFlt-1 and sENG and performed in vitro assays of endothelial dysfunction. Combining esomeprazole and sulfasalazine in lower concentrations caused an additive reduction in sFlt-1 secretion in primary cytotrophoblasts, placental …
We assessed secretion of sFlt-1 and sENG and performed in vitro assays of endothelial dysfunction. Combining esomeprazole and …
Placental expression of sFlt-1 and PlGF in early preeclampsia vs. early IUGR vs. age-matched healthy pregnancies.
Hoeller A, Ehrlich L, Golic M, Herse F, Perschel FH, Siwetz M, Henrich W, Dechend R, Huppertz B, Verlohren S. Hoeller A, et al. Hypertens Pregnancy. 2017 May;36(2):151-160. doi: 10.1080/10641955.2016.1273363. Epub 2017 Feb 10. Hypertens Pregnancy. 2017. PMID: 28609172
OBJECTIVE: To investigate whether differences between early preeclampsia and early fetal growth restriction can be explained by differential placental expression patterns of sFlt-1, Flt-1, and PlGF. METHODS: Placental tissues and maternal blood samples from s …
OBJECTIVE: To investigate whether differences between early preeclampsia and early fetal growth restriction can be explained by differential …
EGFR (Epidermal Growth Factor Receptor) Signaling and the Mitochondria Regulate sFlt-1 (Soluble FMS-Like Tyrosine Kinase-1) Secretion.
Hastie R, Brownfoot FC, Pritchard N, Hannan NJ, Cannon P, Nguyen V, Palmer K, Beard S, Tong S, Kaitu'u-Lino TJ. Hastie R, et al. Hypertension. 2019 Mar;73(3):659-670. doi: 10.1161/HYPERTENSIONAHA.118.12300. Hypertension. 2019. PMID: 30636550
However, the upstream mechanisms regulating release of sFlt-1 are poorly characterized. We investigated the roles of key prosurvival pathways, EGFR (epidermal growth factor receptor) signaling, and the mitochondria, in regulating sFlt-1 production. ... …
However, the upstream mechanisms regulating release of sFlt-1 are poorly characterized. We investigated the roles of key prosu …
YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia.
Brownfoot FC, Tong S, Hannan NJ, Hastie R, Cannon P, Tuohey L, Kaitu'u-Lino TJ. Brownfoot FC, et al. Mol Cell Endocrinol. 2015 Sep 15;413:202-8. doi: 10.1016/j.mce.2015.06.033. Epub 2015 Jul 6. Mol Cell Endocrinol. 2015. PMID: 26159901
It is caused by intermittent placental hypoxia and release of sFlt-1 and soluble endoglin, leading to wide spread maternal endothelial dysfunction and multisystem organ injury. YC-1 is a guanylyl cyclase activator and HIF1alpha inhibitor developed for use in hyperte …
It is caused by intermittent placental hypoxia and release of sFlt-1 and soluble endoglin, leading to wide spread maternal end …
161 results